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A microarray-based DNA methylation study of glioblastoma multiforme

16 May 2009

Abstract excerpt

Glioblastoma multiforme (GBM) is the most frequent and devastating primary brain tumor in adults. The presence of epigenetic lesions, like hypermethylation of known tumor suppressor genes such as MGMT, has been widely described in GBM, but to our knowledge, a genome-wide profile of DNA methylation changes in these lethal tumors is not yet available. In the present analysis, we have quantified the DNA methylation...

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PMID: 19550145
DOI: 10.4161/epi.9130

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