ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells

Abstract excerpt

ABCC11 (Multidrug resistance protein 8; MRP8), a plasma membrane ATP-binding cassette transporter, has been implicated in drug resistance of breast cancer by virtue of its ability to confer resistance to fluoropyrimidines and to efflux methotrexate, and by its expression in this tumor. Expression of ABCC11 in breast, a hormonally regulated tissue, as well as the pump's ability to transport estrogen conjugates,...

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