Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glutathione S-transferase M1-null genotype as risk factor for SOS in oxaliplatin-treated patients with metastatic colorectal cancer.

British journal of cancer - 19 Feb 2013

Vreuls C P H, Olde Damink S W M, Koek G H, Winstanley A, Wisse E, Cloots R H E, van den Broek M A J, Dejong C H C, Bosman F T, Driessen A

Abstract excerpt

BACKGROUND: Oxaliplatin is used as a neo-adjuvant therapy in hepatic colorectal carcinoma metastasis. This treatment has significant side effects, as oxaliplatin is toxic to the sinusoidal endothelial cells and can induce sinusoidal obstruction syndrome (SOS), which is related to decreased overal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antineoplastic Agents
Share to Colorectal Neoplasms
Share to Follow-Up Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione Transferase

Share to Liver Neoplasms

Share to Organoplatinum Compounds

Share to Oxaliplatin

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 23287989
DOI: 10.1038/bjc.2012.590
PMCID: PMC3593549

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23287989-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glutathione S-transferase M1-null genotype as risk factor for SOS in oxaliplatin-treated patients with metastatic colorectal cancer.PMID 23287989Read ↗

Investigating Genetic Risk to Oxaliplatin-Induced Sinusoidal Obstruction Syndrome in Colorectal Cancer Through Routinely Available Next-Generation Sequencing Data.Semantic proximity Read ↗

GSTM1 and GSTP1 Polymorphisms Affect Outcome in Colorectal Adenocarcinoma.Semantic proximity Read ↗

Genetic predisposition resulting in sinusoidal obstruction syndrome in a patient with resected sigmoid cancer on adjuvant oxaliplatin.Semantic proximity Read ↗

Clinical and genetic factors involved in Porto-sinusoidal vascular disorder after oxaliplatin exposure.Semantic proximity Read ↗

The diagnostic potential of glutathione S-transferase (GST) polymorphisms in patients with colorectal cancer.Semantic proximity Read ↗

An experimental study to identify the potential role of pharmacogenomics in determining the occurrence of oxaliplatin-induced liver injury.Semantic proximity Read ↗

Platinum/paclitaxel-based chemotherapy in advanced ovarian carcinoma: glutathione S-transferase genetic polymorphisms as predictive biomarkers of disease outcome.Semantic proximity Read ↗

Polymorphisms in sulfotransferase 1A1 and glutathione S-transferase P1 genes in relation to colorectal cancer risk and patients' survival.Semantic proximity Read ↗

[Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy].Semantic proximity Read ↗

Association between high antitumor activity of oxaliplatin and cyclophosphamide and constitutional GSTM1 homozygous deletion in an advanced ovarian cancer patient.Semantic proximity Read ↗

Potential role of glutathione S‑transferase M1 gene polymorphism in kidney calcium oxalate stone formation.Semantic proximity Read ↗

Genetic polymorphisms in GST genes and survival of colorectal cancer patients treated with chemotherapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.