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Article

Investigating Genetic Risk to Oxaliplatin-Induced Sinusoidal Obstruction Syndrome in Colorectal Cancer Through Routinely Available Next-Generation Sequencing Data.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2026

Zhang Mengxue, Wang Peng, Kong Yang, Gaudio Daniela D, Parente Nick, Hayden Ashley, Setia Namrata, Hart John

Abstract excerpt

Sinusoidal obstruction syndrome (SOS) is a known adverse effect of oxaliplatin, causing significant morbidity and cessation of chemotherapy. Recent studies suggest single-nucleotide polymorphisms of certain genes may predispose carriers to oxaliplatin-induced liver toxicity. This study aims to evaluate candidate SOS-predisposing single-nucleotide polymorphisms by correlating routinely available next-generation...

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Identifiers

PMID: 41786212
DOI: 10.1016/j.modpat.2026.100988

Genes

ERCC1
ABCB1
ABCC2
DPYD
ERCC2
GSTM1
GSTP1
GSTT1
MTHFR
UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Investigating Genetic Risk to Oxaliplatin-Induced Sinusoidal Obstruction Syndrome in Colorectal Cancer Through Routinely Available Next-Generation Sequencing Data.PMID 41786212Read ↗

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