Article
The SPS affair: a complex tale of illicit proliferation.
Cancer cell - 4 Aug 2009
Braun Benjamin S, Shannon Kevin
Abstract excerpt
In this issue of Cancer Cell, Xiao et al. report that PLC-beta3 mutant mice develop myeloprolfierative neoplasms and show that tumor suppressor activity does not require PLC-beta3 catalytic activity. Instead, PLC-beta3 forms a complex with SHP-1 and Stat5 that facilitates Stat5 dephosphorylation....
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