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Article

Using family-based imputation in genome-wide association studies with large complex pedigrees: the Framingham Heart Study.

PloS one - 1 Jan 2012

Chen Ming-Huei, Huang Jie, Chen Wei-Min, Larson Martin G, Fox Caroline S, Vasan Ramachandran S, Seshadri Sudha, O'Donnell Christopher J, Yang Qiong

Abstract excerpt

Imputation has been widely used in genome-wide association studies (GWAS) to infer genotypes of un-genotyped variants based on the linkage disequilibrium in external reference panels such as the HapMap and 1000 Genomes. However, imputation has only rarely been performed based on family relationships to infer genotypes of un-genotyped individuals. Using 8998 Framingham Heart Study (FHS) participants genotyped with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23284720
DOI: 10.1371/journal.pone.0051589
PMCID: PMC3524237

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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