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Article

ncDNA and drift drive binding site accumulation.

BMC evolutionary biology - 30 Aug 2012

Ruths Troy, Nakhleh Luay

Abstract excerpt

BACKGROUND: The amount of transcription factor binding sites (TFBS) in an organism's genome positively correlates with the complexity of the regulatory network of the organism. However, the manner by which TFBS arise and accumulate in genomes and the effects of regulatory network complexity on the organism's fitness are far from being known. The availability of TFBS data from many organisms provides an...

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PMID: 22935101
DOI: 10.1186/1471-2148-12-159
PMCID: PMC3556125

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