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Article

Laminin alpha 2 enables glioblastoma stem cell growth

22 Jun 2012

Abstract excerpt

OBJECTIVE: Glioblastomas (GBMs) are lethal cancers that display cellular hierarchies parallel to normal brain. At the apex are GBM stem cells (GSCs), which are relatively resistant to conventional therapy. Interactions with the adjacent perivascular niche are an important driver of malignancy and self-renewal in GSCs. Extracellular matrix (ECM) cues instruct neural stem/progenitor cell-niche interactions, and the...

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PMID: 23280793
DOI: 10.1002/ana.23674

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