Article

Identification of established and novel extracellular matrix components in glioblastoma as targets for angiogenesis and prognosis

2024-03-04

Abstract excerpt

Glioblastomas (GBM) are aggressive tumors known for their heterogeneity, rapid proliferation, treatment resistance, and extensive vasculature. Angiogenesis, the formation of new vessels, involves endothelial cell (EC) migration and proliferation. Various extracellular matrix (ECM) molecules regulate EC survival, migration, and proliferation. Culturing human brain EC (HBMEC) on GBM-derived ECM revealed a decrease i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 651b0eaa-ffff-55f7-b225-794f0c56688f
DOI: 10.1101/2024.02.28.24303381

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of established and novel extracellular matrix components in glioblastoma as targets for angiogenesis and prognosisDOI 10.1101/2024.02.28.24303381Read

Extracellular Matrix Proteome Remodeling in Human Glioblastoma and MedulloblastomaSemantic proximity Read

Molecular markers of extracellular matrix remodeling in glioblastoma vessels: Microarray study of laser‐captured glioblastoma vesselsSemantic proximity Read

Single Cell Spatial Profiling Identifies Region-Specific Extracellular Matrix Adhesion and Signaling Networks in GlioblastomaSemantic proximity Read

Blood-brain barrier alterations in human brain tumors revealed by genome-wide transcriptomic profilingSemantic proximity Read

TGF-β induces oncofetal fibronectin that, in turn, modulates TGF-β superfamily signaling in endothelial cellsSemantic proximity Read

Laminin alpha 2 enables glioblastoma stem cell growthSemantic proximity Read

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene SignaturesSemantic proximity Read

Overview of Transforming Growth Factor β Superfamily Involvement in Glioblastoma Initiation and ProgressionSemantic proximity Read

Paradoxical role of β8 integrin on angiogenesis and vasculogenic mimicry in glioblastomaSemantic proximity Read

A prognostic matrix gene expression signature defines functional glioblastoma phenotypes and nichesSemantic proximity Read

DNA Methylation-based Diagnostic and Prognostic Biomarkers for GlioblastomaSemantic proximity Read

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of GlioblastomaSemantic proximity Read