Article
Concentration of tacrolimus and major metabolites in kidney transplant recipients as a function of diabetes mellitus and cytochrome P450 3A gene polymorphism.
Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2013
Chitnis Shripad D, Ogasawara Ken, Schniedewind Björn, Gohh Reginald Y, Christians Uwe, Akhlaghi Fatemeh
Abstract excerpt
1. Disposition of tacrolimus and its major metabolites, 13-O-desmethyl tacrolimus and 15-O-desmethyl tacrolimus, was evaluated in stable kidney transplant recipients in relation to diabetes mellitus and genetic polymorphism of cytochrome P450 (CYP) 3A. 2. Steady-state concentration-time profiles were obtained for 12-hour or 2-hour post-dose, in 20 (11 with diabetes) and 32 (24 with diabetes) patients,...
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