Article
The effects of the CYP3A5*3 variant on tacrolimus pharmacokinetics and outcomes in Tunisian kidney transplant recipients.
La Tunisie medicale - 5 Oct 2023
Charfi Rim, Bacha Mohamed Mongi, Ben Fadhal Myriam, Ferchichi Khouloud, El Jebari Hanene, Gaies Emna, Klouz Anis, Abderrahim Ezzeddine, Ben Hamida Fathi, Ben Abdallah Taieb, Trabelsi Sameh, Gorgi Yosr, Sfar Imen
Abstract excerpt
INTRODUCTION: Tacrolimus, exhibits interindividual pharmacokinetic variability and a narrow therapeutic index. The influence of the CYP3A5 6986A>G single nucleotide polymorphism (SNP) on this variability remains a topic of debate. AIM: To assess the impact of the aforementioned SNP on tacrolimus area under curve (AUC0-12h), adverse drug reactions (ADRs), and kidney graft outcomes. METHODS: Blood samples were...
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