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Article

Long-range protein-water dynamics in hyperactive insect antifreeze proteins.

Proceedings of the National Academy of Sciences of the United States of America - 29 Jan 2013

Meister Konrad, Ebbinghaus Simon, Xu Yao, Duman John G, DeVries Arthur, Gruebele Martin, Leitner David M, Havenith Martina

Abstract excerpt

Antifreeze proteins (AFPs) are specific proteins that are able to lower the freezing point of aqueous solutions relative to the melting point. Hyperactive AFPs, identified in insects, have an especially high ability to depress the freezing point by far exceeding the abilities of other AFPs. In previous studies, we postulated that the activity of AFPs can be attributed to two distinct molecular mechanisms: (i)...

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Identifiers

PMID: 23277543
DOI: 10.1073/pnas.1214911110
PMCID: PMC3562781

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Source receipt: pubmed, retrieved 7 Sept 2026.

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