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Article

Engineering a naturally inactive isoform of type III antifreeze protein into one that can stop the growth of ice.

FEBS letters - 2 Nov 2012

Garnham Christopher P, Nishimiya Yoshiyuki, Tsuda Sakae, Davies Peter L

Abstract excerpt

Type III antifreeze proteins (AFPs) can be sub-divided into three classes of isoforms. SP and QAE2 isoforms can slow, but not stop, the growth of ice crystals by binding to pyramidal ice planes. The other class (QAE1) binds both pyramidal and primary prism planes and is able to halt the growth of ice. Here we describe the conversion of a QAE2 isoform into a fully-active QAE1-like isoform by changing four...

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Identifiers

PMID: 23017208
DOI: 10.1016/j.febslet.2012.09.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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