Article
Proline-mediated conformational rigidity governs the ice-binding behavior of antifreeze glycopeptides.
Physical chemistry chemical physics : PCCP - 22 Apr 2026
Zhang Jingwen, Wang Haipeng, Liu Xuyang, Shao Xueguang, Cai Wensheng
Abstract excerpt
Antifreeze glycoproteins (AFGPs) are among the most potent inhibitors of ice recrystallization, yet the conformational basis of their activity and the effects of proline mutations in short AFGP peptides remain unclear. Here, molecular dynamics simulations were used to examine the interfacial conformations and ice-growth inhibition of the minimal antifreeze peptide AFGP8 and its variants P7A, P13A, and P7A/P13A on...
Topics
- Antifreeze Proteins
- Proline
- Molecular Dynamics Simulation
- Ice
- Protein Conformation
- Glycopeptides
- Protein Binding
- Mutation
- Hydrophobic and Hydrophilic Interactions