Article
Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 2013
Oruganty Krishnadev, Talathi Nakul Suhas, Wood Zachary A, Kannan Natarajan
Abstract excerpt
The protein kinase catalytic domain contains several conserved residues of unknown functions. Here, using a combination of computational and experimental approaches, we show that the function of some of these residues is to maintain the backbone geometry of the active site in a strained conformation. Specifically, we find that the backbone geometry of the catalytically important HRD motif deviates from ideality...
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