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Article

Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153.

The Journal of general physiology - 1 Jan 2013

Jadey Snehal, Purohit Prasad, Auerbach Anthony

Abstract excerpt

A primary target for nicotine is the acetylcholine receptor channel (AChR). Some of the ability of nicotine to activate differentially AChR subtypes has been traced to a transmitter-binding site amino acid that is glycine in lower affinity and lysine in higher affinity AChRs. We studied the effects of mutations of this residue (αG153) in neuromuscular AChRs activated by nicotine and eight other agonists including...

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Identifiers

PMID: 23277476
DOI: 10.1085/jgp.201210896
PMCID: PMC3536520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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