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Article

Mutation of Val90 to His in the pseudoperoxidase from Leishmania major enhances peroxidase activity.

Biochimica et biophysica acta - 1 Mar 2013

Saha Rina, Bose Moumita, Adak Subrata

Abstract excerpt

Pseudoperoxidase from Leishmania major (LmPP) catalyzes the breakdown of peroxynitrite though it can hardly react with H(2)O(2). Our modeling structure predicts that a conserved His to Val switch near the distal heme pocket of LmPP may determine the profile of its H(2)O(2) activity. To test this hypothesis, we have generated complementary mutations in the LmPP (V90H) and studied the formation of Compounds I and...

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Source

Identifiers

PMID: 23277197
DOI: 10.1016/j.bbapap.2012.12.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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