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Article

Effect of distal His mutation on the peroxynitrite reactivity of Leishmania major peroxidase.

Biochimica et biophysica acta - 1 Oct 2013

Saha Rina, Bose Moumita, Santara Sumit Sen, Roy Jayasree, Yadav Rajesh K, Adak Subrata

Abstract excerpt

The conserved distal histidine in peroxidases has been considered to play a major role as a general acid-base catalyst for heterolytic cleavage of an OO bond in H2O2. However, heme peroxidases react with peroxynitrite to form transient intermediates but the role of the distal histidine in this reaction is still unknown. In order to investigate catalytic roles of the histidine at the distal cavity, two Leishmania...

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Identifiers

PMID: 23831153
DOI: 10.1016/j.bbapap.2013.06.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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