Article
A Suicide Mutation Affecting Proton Transfers to High-Valent Hemes Causes Inactivation of MauG during Catalysis.
Biochemistry - 11 Oct 2016
Ma Zhongxin, Williamson Heather R, Davidson Victor L
Abstract excerpt
In the absence of its substrate, the autoreduction of the high-valent bis-FeIV state of the hemes of MauG to the diferric state proceeds via a Compound I-like and then a Compound II-like intermediate. This process is coupled to oxidative damage to specific methionine residues and inactivation of MauG. The autoreduction of a P107V MauG variant, which is more prone to oxidative damage, proceeds directly from the...
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