Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular evolution of peptide ligands with custom-tailored characteristics for targeting of glycostructures.

PLoS computational biology - 1 Jan 2012

Röckendorf Niels, Borschbach Markus, Frey Andreas

Abstract excerpt

As an advanced approach to identify suitable targeting molecules required for various diagnostic and therapeutic interventions, we developed a procedure to devise peptides with customizable features by an iterative computer-assisted optimization strategy. An evolutionary algorithm was utilized to breed peptides in silico and the "fitness" of peptides was determined in an appropriate laboratory in vitro assay. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to Amino Acid Sequence
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Dyes

Share to G(M1) Ganglioside

Share to Ligands

Share to Molecular Sequence Data

Share to Peptides

Source

Open in PubMed Open full text

Identifiers

PMID: 23271960
DOI: 10.1371/journal.pcbi.1002800
PMCID: PMC3521706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular evolution of peptide ligands with custom-tailored characteristics for targeting of glycostructures.PMID 23271960Read ↗

Peptide design by artificial neural networks and computer-based evolutionary searchSemantic proximity Read ↗

Machine learning-based development of Gadolinium binding peptidesSemantic proximity Read ↗

Antibody biomarker discovery through in vitro directed evolution of consensus recognition epitopesSemantic proximity Read ↗

Protein evolution with an expanded genetic codeSemantic proximity Read ↗

Evolution of proteins with genetically encoded "chemical warheads".Semantic proximity Read ↗

Computationally optimized deimmunization libraries yield highly mutated enzymes with low immunogenicity and enhanced activity.Semantic proximity Read ↗

A multiobjective evolutionary method for the design of peptidic mimotopes.Semantic proximity Read ↗

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic LinkageSemantic proximity Read ↗

Chemical chaperone therapy: clinical effect in murine G(M1)-gangliosidosis.Semantic proximity Read ↗

Computational peptide discovery with a genetic programming approachSemantic proximity Read ↗

A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis.Semantic proximity Read ↗

Protein Optimization Evolving Tool (POET) based on Genetic ProgrammingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.