Peptide design by artificial neural networks and computer-based evolutionary search

Abstract excerpt

A technique for systematic peptide variation by a combination of rational and evolutionary approaches is presented. The design scheme consists of five consecutive steps: (i) identification of a "seed peptide" with a desired activity, (ii) generation of variants selected from a physicochemical space around the seed peptide, (iii) synthesis and testing of this biased library, (iv) modeling of a quantitative...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chemical Synthesis and Analysis
• Share to Monoclonal and Polyclonal Antibodies Research
• Share to Receptor Mechanisms and Signaling