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Biosynthetic Multitasking Facilitates Thalassospiramide Structural Diversity in Marine Bacteria

27 Dec 2012

Abstract excerpt

Thalassospiramides A and B are immunosuppressant cyclic lipopeptides first reported from the marine α-proteobacterium Thalassospira sp. CNJ-328. We describe here the discovery and characterization of an extended family of 14 new analogues from four Tistrella and Thalassospira isolates. These potent calpain 1 protease inhibitors belong to six structure classes in which the length and composition of the acylpeptide...

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PMID: 23270364
DOI: 10.1021/ja3119674

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