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Article

In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.

BMC genomics - 30 Nov 2010

Marsh Alan J, O'Sullivan Orla, Ross R Paul, Cotter Paul D, Hill Colin

Abstract excerpt

BACKGROUND: Lantibiotics are lanthionine-containing, post-translationally modified antimicrobial peptides. These peptides have significant, but largely untapped, potential as preservatives and chemotherapeutic agents. Type 1 lantibiotics are those in which lanthionine residues are introduced into the structural peptide (LanA) through the activity of separate lanthionine dehydratase (LanB) and lanthionine...

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Identifiers

PMID: 21118552
DOI: 10.1186/1471-2164-11-679
PMCID: PMC3091789

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