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Discovery of Unique Lanthionine Synthetases Reveals New Mechanistic and Evolutionary Insights

22 Mar 2010

Abstract excerpt

Lantibiotic synthetases are remarkable biocatalysts generating conformationally constrained peptides with a variety of biological activities by repeatedly utilizing two simple posttranslational modification reactions: dehydration of Ser/Thr residues and intramolecular addition of Cys thiols to the resulting dehydro amino acids. Since previously reported lantibiotic synthetases show no apparent homology with any...

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PMID: 20351769
DOI: 10.1371/journal.pbio.1000339

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