Article
N-Acetylation of drugs. A genetically controlled reciprocal relationship between drug N-acetylating enzymes of rabbit liver and peripheral blood cells.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Szabadi R R, McQueen C A, Drummond G S, Weber W W
Abstract excerpt
The reciprocal relation between liver isoniazid N-acetyltransferase and blood p-aminobenzoic and N-acetyltransferase previously reported is confirmed and found to be expressed in erythrocytes and lymphocytes of genetically rapid and slow isoniazid-acetylator rabbits. Both erythrocytes and lymphocytes from slow acetylator rabbits contained 2.5-3.3 times as much p-aminobenzoic acid N-acetyltransferase activity as...
Topics
- 4-Aminobenzoic Acid
- Acetyltransferases
- Aging
- Animals
- Erythrocytes
- Female
- In Vitro Techniques
- Isoniazid
- Liver
- Lymphocytes
- Male