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Article

Clinical significance of ESR1 gene copy number changes in breast cancer as measured by fluorescence in situ hybridisation.

Journal of clinical pathology - 1 Feb 2013

Lin Ching-Hung, Liu Jacqueline M, Lu Yen-Shen, Lan Chieh, Lee Wei-Chung, Kuo Kuan-Ting, Wang Chung-Chieh, Chang Dwan-Ying, Huang Chiun-Sheng, Cheng Ann-Lii

Abstract excerpt

AIMS: The ESR1 gene encodes for oestrogen receptor (ER) α, which plays a crucial role in mammary carcinogenesis and clinical outcome in patients with breast cancer. However, the clinical significance of the ESR1 gene copy number change for breast cancer has not been clarified. METHODS: ESR1 gene copy number was determined by fluorescence in situ hybridisation (FISH) on tissue sections. A minimum of 20 tumour...

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Source

Identifiers

PMID: 23268322
DOI: 10.1136/jclinpath-2012-200929

Genes

ESR1
ASXL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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