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Estrogen Receptor Gene Polymorphism as a Possible Genetic Risk Factor for Treatment Response in ER-Positive Breast Cancer Patients.

Biochemical genetics - 1 Dec 2022

Allahloubi Nasr M A, Zekri Abdel-Rahman N, Ragab Mohamed, Mohanad Marwa, Ahmed Ola S, Eid Salem, Ghareeb Mohamed, Gouda Iman, Bahnassy Abeer A

Abstract excerpt

Estrogen receptor-α (ESR1) single nucleotide polymorphisms (SNPs) have been related to breast cancer (BC) susceptibility. In this retrospective study we investigated ESR1 SNPs in association with survival and treatment response in BC patients. Seven ESR1 SNPs were genotyped using TaqMan probe assay in 100 formalin-fixed paraffin embedded blocks of Egyptian ER+BC patients. Log-binomial regression was used to...

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PMID: 35182276
DOI: 10.1007/s10528-022-10199-3

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