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Estrogen receptor α gene <i>ESR1</i> amplification may predict endocrine therapy responsiveness in breast cancer patients

25 Feb 2009

Abstract excerpt

Estrogen receptor (ER) alpha plays a crucial role in normal breast development and has also been linked to mammary carcinogenesis and clinical outcome in breast cancer patients. However, the molecular mechanisms controlling the expression of ERalpha are as yet not fully understood. Gene amplification is one of the important factors regulating protein expression. Recent studies on the amplification of the ESR1...

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PMID: 19320640
DOI: 10.1111/j.1349-7006.2009.01145.x

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