Gene amplification of <i>ESR1</i> in breast cancers—fact or fiction? A fluorescence <i>in situ</i> hybridization and multiplex ligation‐dependent probe amplification study

Abstract excerpt

Oestrogen receptor-alpha (ERα), encoded by the ESR1 gene located on 6q25, is a nuclear transcription factor. Since it was reported in 2007 that more than 20% of breast cancers show ESR1 gene amplification, there has been considerable controversy about its frequency and clinical significance. We set out to assess the frequency and levels of ESR1 amplification in breast cancers. In a total of 106 breast needle...

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