Article
FMO3 allelic variants in Sicilian and Sardinian populations: trimethylaminuria and absence of fish-like body odor.
Gene - 25 Feb 2013
D'Angelo Rosalia, Esposito Teresa, Calabrò Marco, Rinaldi Carmela, Robledo Renato, Varriale Bruno, Sidoti Antonina
Abstract excerpt
The N-oxygenation of amines by the human flavin-containing monooxygenase (form 3) (FMO3) represents an important means for the conversion of lipophilic nucleophilic heteroatom-containing compounds into more polar and readily excreted products. In healthy individuals, virtually all Trimethylamine (TMA) are metabolized to Trimethylamine N-oxide (TMAO). Several single nucleotide polymorphisms (SNPs) of the FMO3 gene...
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