Article
Case-control study of HLA-G promoter methylation status, HPV infection and cervical neoplasia in Curitiba, Brazil: a pilot analysis.
BMC cancer - 24 Dec 2012
Gillio-Tos Anna, Bicalho Maria da Graça, Fiano Valentina, Grasso Chiara, Tarallo Valentina, De Marco Laura, Trevisan Morena, Xavier Marinabarbaradesousa, Slowik Renata, Carvalho Newton S, Maestri Carlos A, Lacerda Hadriano M, Zugna Daniela, Richiardi Lorenzo, Merletti Franco
Abstract excerpt
BACKGROUND: The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has been established, but the mechanisms that favor HPV persistence in cervical cells are still unknown. The diminished capability of the immune system to control and resolve HPV infection is one of several hypotheses. The tolerogenic protein HLA-G has shown aberrant expression in a variety of cancers,...
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