Article
HPV-Driven Cervical Carcinogenesis: Genetic and Epigenetic Mechanisms and Diagnostic Approaches.
International journal of molecular sciences - 13 Jan 2026
Legaki Evangelia, Lappa Theofania, Prasoula Konstantina-Lida, Kardasi Zoi, Kalampokas Emmanouil, Kalampokas Theodoros, Roubelakis Maria G, Charvalos Ekaterina, Gazouli Maria
Abstract excerpt
Cervical cancer remains a major global public health concern, with persistent infection by high-risk human papillomavirus (hrHPV) types recognized as the primary etiological factor. This review explores the multifactorial nature of the disease, focusing on the complex interplay between host genetic susceptibility and epigenetic alterations that drive cervical carcinogenesis. Evidence from genome-wide association...
Topics
- Humans
- Uterine Cervical Neoplasms
- Epigenesis, Genetic
- Human Papillomavirus Viruses
- Female
- DNA Methylation
- Papillomavirus Infections
- Genome-Wide Association Study
- Genetic Predisposition to Disease