Cdx4 dysregulates <i>Hox</i> gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model

Abstract excerpt

HOX genes have emerged as critical effectors of leukemogenesis, but the mechanisms that regulate their expression in leukemia are not well understood. Recent data suggest that the caudal homeobox transcription factors CDX1, CDX2, and CDX4, developmental regulators of HOX gene expression, may contribute to HOX gene dysregulation in leukemia. We report here that CDX4 is expressed normally in early hematopoietic...

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