Article
Expression analysis of B-Raf oncogene in V600E-negative benign and malignant tumors of the thyroid gland: correlation with late disease onset.
Medical oncology (Northwood, London, England) - 1 Mar 2013
Derdas Stavros P, Soulitzis Nikolaos, Balis Vasileios, Sakorafas Georgios H, Spandidos Demetrios A
Abstract excerpt
B-Raf, a member of the Raf serine/threonine kinase family, is an intermediate molecule in the mitogen-activated protein kinase pathway, which relays extracellular signals from the cell membrane to the nucleus via a cascade of phosphorylation events, ultimately promoting cancer development. This pathway is usually activated in human neoplasias. The purpose of this study was to investigate the role of B-Raf in...
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