Article
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010
Nucera Carmelo, Porrello Alessandro, Antonello Zeus Andrea, Mekel Michal, Nehs Matthew A, Giordano Thomas J, Gerald Damien, Benjamin Laura E, Priolo Carmen, Puxeddu Efisio, Finn Stephen, Jarzab Barbara, Hodin Richard A, Pontecorvi Alfredo, Nose Vânia, Lawler Jack, Parangi Sareh
Abstract excerpt
Although B-Raf(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC), how it induces tumor aggressiveness is not fully understood. Using gene set enrichment analysis and in vitro and in vivo functional studies, we identified and validated a B-Raf(V600E) gene set signature associated with tumor progression in PTCs. An independent cohort of B-Raf(V600E)-positive PTCs showed significantly...
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