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Article

Low intrinsic exercise capacity in rats predisposes to age-dependent cardiac remodeling independent of macrovascular function.

American journal of physiology. Heart and circulatory physiology - 1 Mar 2013

Ritchie Rebecca H, Leo Chen Huei, Qin Chengxue, Stephenson Erin J, Bowden Marissa A, Buxton Keith D, Lessard Sarah J, Rivas Donato A, Koch Lauren G, Britton Steven L, Hawley John A, Woodman Owen L

Abstract excerpt

Rats selectively bred for low (LCR) or high (HCR) intrinsic running capacity simultaneously present with contrasting risk factors for cardiovascular and metabolic disease. However, the impact of these phenotypes on left ventricular (LV) morphology and microvascular function, and their progression with aging, remains unresolved. We tested the hypothesis that the LCR phenotype induces progressive age-dependent LV...

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Identifiers

PMID: 23262135
DOI: 10.1152/ajpheart.00638.2012
PMCID: PMC3833993

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