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Article

Rats selectively bred for differences in aerobic capacity have similar hypertensive responses to chronic intermittent hypoxia.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2013

Sharpe Amanda L, Andrade Mary Ann, Herrera-Rosales Myrna, Britton Steven L, Koch Lauren G, Toney Glenn M

Abstract excerpt

Exposure to chronic intermittent hypoxia (CIH) is an animal model that mimics the repetitive bouts of hypoxemia experienced by humans with sleep apnea. Rats exposed to CIH develop hypertension that depends on the activation of sympathetic nerve activity (SNA). Since obesity and metabolic syndrome have been linked to neurogenic hypertension and sleep apnea, and because sleep apnea can adversely affect aerobic...

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Identifiers

PMID: 23709603
DOI: 10.1152/ajpheart.00317.2013
PMCID: PMC3742873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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