Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma

22 Dec 2012

Abstract excerpt

BACKGROUND: The aim of this study was to clarify the role of global hypomethylation of repetitive elements in determining the genetic and clinical features of multiple myeloma (MM). METHODS: We assessed global methylation levels using four repetitive elements (long interspersed nuclear element-1 (LINE-1), Alu Ya5, Alu Yb8, and Satellite-α) in clinical samples comprising 74 MM samples and 11 benign control samples...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Chromosomal and Genetic Variations
Share to Multiple Myeloma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23259664
DOI: 10.1186/gm402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myelomaPMID 23259664Read ↗

Methylation variability and LINE-1 activation in multiple myelomaSemantic proximity Read ↗

DNA Methylation Analysis Determines the High Frequency of Genic Hypomethylation and Low Frequency of Hypermethylation Events in Plasma Cell TumorsSemantic proximity Read ↗

Genome instability in multiple myeloma.Semantic proximity Read ↗

Aberrant DNA methylation in multiple myeloma: A major obstacle or an opportunity?Semantic proximity Read ↗

Genetic Abnormalities in Extramedullary Multiple MyelomaSemantic proximity Read ↗

Epigenetic Aberrations in Multiple MyelomaSemantic proximity Read ↗

The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myelomaSemantic proximity Read ↗

Aberrant global methylation patterns affect the molecular pathogenesis and prognosis of multiple myelomaSemantic proximity Read ↗

A compendium of myeloma-associated chromosomal copy number abnormalities and their prognostic value.Semantic proximity Read ↗

Epigenetic Plasticity Drives Carcinogenesis and Multi-Therapy Resistance in Multiple MyelomaSemantic proximity Read ↗

The Multiple Myeloma Landscape: Epigenetics and Non-Coding RNAsSemantic proximity Read ↗

Epigenetic reprogramming in multiple myeloma—Challenges and opportunitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.