Genetic Abnormalities in Extramedullary Multiple Myeloma

Abstract excerpt

Extramedullary multiple myeloma (or extramedullary disease, EMD) is an aggressive form of multiple myeloma (MM) that occurs when malignant plasma cells become independent of the bone marrow microenvironment. This may occur alongside MM diagnosis or in later stages of relapse and confers an extremely poor prognosis. In the era of novel agents and anti-myeloma therapies, the incidence of EMD is increasing, making...

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• Cancer Mechanisms and Therapy
• Multiple Myeloma Research and Treatments
• Protein Degradation and Inhibitors