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Article

The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells

20 Dec 2012

Abstract excerpt

INTRODUCTION: Glioblastoma multiforme (GBM; World Health Organization astrocytoma grade IV) is the most frequent and most malignant primary brain tumor in adults. Despite multimodal therapy, all such tumors practically recur during the course of therapy, causing a median survival of only 14.6 months in patients with newly diagnosed GBM. The present study was aimed at examining the expression of the DNA repair...

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PMID: 23258843
DOI: 10.1093/neuonc/nos301

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