Article
HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea.
Neuro-oncology - 1 Sept 2010
Jin Genglin, Cook Stephen, Cui Bo, Chen William C, Keir Stephen T, Killela Patrick, Di Chunhui, Payne Cathy A, Gregory Simon G, McLendon Roger, Bigner Darell D, Yan Hai
Abstract excerpt
Glioblastoma multiforme (GBM) is one of the deadliest tumors afflicting humans, and the mechanisms of its onset and progression remain largely undefined. Our attempts to elucidate its molecular pathogenesis through DNA copy-number analysis by genome-wide digital karyotyping and single nucleotide polymorphism arrays identified a dramatic focal amplification on chromosome 1q32 in 4 of 57 GBM tumors. Quantitative...
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