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The AlkB Family: Potential Prognostic Biomarkers and Therapeutic Targets in Glioblastoma

10 Mar 2022

Abstract excerpt

The AlkB family of Fe (II) and α-ketoglutarate-dependent dioxygenases works by removing alkyl substituents from alkylation-damaged nucleic acid bases through oxidative dealkylation, subsequently affecting tumor progression and patient prognosis. However, the specific roles of the AlkB family in Glioblastoma remain to be elucidated. By taking advantage of the abundant bioinformatics databases, such as GEPIA2,...

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PMID: 35371987
DOI: 10.3389/fonc.2022.847821

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