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Article

Loss of AIRE-Mediated Immune Tolerance and the Skin.

The Journal of investigative dermatology - 1 Mar 2022

Peterson Pärt, Kisand Kai, Kluger Nicolas, Ranki Annamari

Abstract excerpt

The core function of the immune response is to distinguish between self and foreign. The multiorgan human autoimmune disease, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED/autoimmune polyendocrine syndrome type 1) is an example of what happens in the body when central immune tolerance goes astray. APECED revealed the existence and function of the autoimmune regulator gene, which has a...

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Identifiers

PMID: 34535292
DOI: 10.1016/j.jid.2021.04.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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