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Article

APOBEC3 proteins can copackage and comutate HIV-1 genomes.

Nucleic acids research - 19 Sept 2016

Desimmie Belete A, Burdick Ryan C, Izumi Taisuke, Doi Hibiki, Shao Wei, Alvord W Gregory, Sato Kei, Koyanagi Yoshio, Jones Sara, Wilson Eleanor, Hill Shawn, Maldarelli Frank, Hu Wei-Shau, Pathak Vinay K

Abstract excerpt

Although APOBEC3 cytidine deaminases A3G, A3F, A3D and A3H are packaged into virions and inhibit viral replication by inducing G-to-A hypermutation, it is not known whether they are copackaged and whether they can act additively or synergistically to inhibit HIV-1 replication. Here, we showed that APOBEC3 proteins can be copackaged by visualization of fluorescently-tagged APOBEC3 proteins using single-virion...

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Identifiers

PMID: 27439715
DOI: 10.1093/nar/gkw653
PMCID: PMC5027510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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