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Article

Molecular dissection of human oncostatin M-mediated signal transductions through site-directed mutagenesis.

International journal of molecular medicine - 1 Feb 2009

Liu Haiyan, Fenollar-Ferrer Cristina, Cao Aiqin, Anselmi Claudio, Carloni Paolo, Liu Jingwen

Abstract excerpt

The binding of oncostatin M (OM) to type I and type II receptor complexes elicits various biological responses by activating MEK/ERK and JAK/STAT signaling pathways. Some OM effects are clinically desirable such as reducing hyperlipidemia through the activation of hepatic LDL receptor transcription, a downstream event of ERK activation. The OM pro-inflammatory responses via induction of acute phase protein gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19148539

Genes

STAT1
STAT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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