Article
Spontaneous mutation rate of measles virus: direct estimation based on mutations conferring monoclonal antibody resistance.
Journal of virology - 1 Jan 1999
Schrag S J, Rota P A, Bellini W J
Abstract excerpt
High mutation rates typical of RNA viruses often generate a unique viral population structure consisting of a large number of genetic microvariants. In the case of viral pathogens, this can result in rapid evolution of antiviral resistance or vaccine-escape mutants. We determined a direct estimate of the mutation rate of measles virus, the next likely target for global elimination following poliovirus. In a...
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