Spontaneous mutation rate of measles virus: direct estimation based on mutations conferring monoclonal antibody resistance.

doi:10.1128/JVI.73.1.51-54.1999

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Article

Spontaneous mutation rate of measles virus: direct estimation based on mutations conferring monoclonal antibody resistance.

Journal of virology - 1 Jan 1999

Schrag S J, Rota P A, Bellini W J

Abstract excerpt

High mutation rates typical of RNA viruses often generate a unique viral population structure consisting of a large number of genetic microvariants. In the case of viral pathogens, this can result in rapid evolution of antiviral resistance or vaccine-escape mutants. We determined a direct estimat...

Topics

Animals
Antibodies, Monoclonal
Chlorocebus aethiops
Hemagglutinins, Viral
Measles virus
Mice
Mutation
Vero Cells

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