Article
Sequencing of serially passaged measles virus affirms its genomic stability and reveals a nonrandom distribution of consensus mutations.
The Journal of general virology - 1 Apr 2020
Leber Mathias Felix, Hoyler Birgit, Prien Stefanie, Neault Serge, Engeland Christine E, Förster Judith M, Bossow Sascha, Springfeld Christoph, von Kalle Christof, Jäger Dirk, Bell John C, Ungerechts Guy
Abstract excerpt
Oncolytic virotherapy is an emerging treatment option for numerous cancers, with several virus families currently being evaluated in clinical trials. More specifically, vaccine-strain measles virus has arisen as a promising candidate for the treatment of different tumour types in several early clinical trials. Replicating viruses, and especially RNA viruses without proofreading polymerases, can rapidly adapt to...
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