Article
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice.
Neurobiology of disease - 1 Jul 2008
de Vrij Femke M S, Levenga Josien, van der Linde Herma C, Koekkoek Sebastiaan K, De Zeeuw Chris I, Nelson David L, Oostra Ben A, Willemsen Rob
Abstract excerpt
Lack of fragile X mental retardation protein (FMRP) causes Fragile X Syndrome, the most common form of inherited mental retardation. FMRP is an RNA-binding protein and is a component of messenger ribonucleoprotein complexes, associated with brain polyribosomes, including dendritic polysomes. FMRP is therefore thought to be involved in translational control of specific mRNAs at synaptic sites. In mice lacking...
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