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Article

The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells

24 Nov 2012

Abstract excerpt

About 20% of breast cancers are characterized by amplification and overexpression of the HER2 oncogene. Although significant progress has been achieved for treating such patients with HER2 inhibitor trastuzumab, more than half of the patients respond poorly or become resistant to the treatment. Since the HER2 amplicon at 17q12 contains multiple genes, we have systematically explored the role of the HER2...

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PMID: 23253899
DOI: 10.1016/j.molonc.2012.10.012

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