Article

Concurrent Mutations Associated With Trastuzumab-resistance Revealed by Single Cell Sequencing

2021-02-25

Abstract excerpt

<title>Abstract</title> <p>Purpose: HER2-positive breast cancer patients benefit from HER2 targeted therapies, among which the most commonly used is trastuzumab. However, acquired resistance typically happens within one year. The cellular heterogeneity of it is less clear. <h4>Methods:</h4> Here we generated trastuzumab-resistant cells in two HER2-positive breast cancer cell lines, SK-BR-3 and BT-474. Cells at di...

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Literature Corpus work: ff4f22b2-8424-5e95-be27-6fa624ee6996
DOI: 10.21203/rs.3.rs-253665/v1

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